Current Research

While there is no question that erectile dysfunction (ED) is a complex condition that is the subject of ongoing investigation in the medical literature, there is also no question that some significant strides have been made in recent years that have resulted in breakthroughs in medical treatment. It has been the increased understanding of the physiological role of nitric oxide that is responsible for the few pharmacological interventions available today.

In their paper titled “Neurophysiological basis of penile erection”, the authors Priviero FB et al state:

“Penile erection involves researcha complex interaction between the central nervous system and local factors. It is a neurovascular event modulated by psychological and hormonal factors. The discovery of nitric oxide (NO) as an intercellular messenger or neurotransmitter paved the way for identifying important mechanisms underlying physiological and pathophysiological events in the penis, in addition to providing the knowledge for the development of new therapeutics based on a novel concept of molecule and cell interaction.”

Dr. Arthur L. Burnett, II, MD is Professor, Department of Urology, at Johns Hopkins University School of Medicine, and in his paper titled “The role of nitric oxide in erectile dysfunction: implications for medical therapy” he states:

“Nitric oxide (NO) is believed to be the main vasoactive neurotransmitter and chemical mediator of penile erection”

There are many articles published to this effect in the medical literature and it is quite clear that nitric oxide has a major role to play in the neurological and vascular interplay that results in erectile function in men. Consequently, the only remaining question relates to whether or not nutrient supplementation can positively affect nitric oxide production. There is a veritable mountain of literature in support of specific nutrient and phytonutrient supplementation to support healthy nitric oxide levels, but for the sake of brevity it would suffice to point out the two nutrients in particular have been proven to be extremely effective: L-citrulline and beet extract.

As recently as December 2013 researchers from Japan published a study titled “Oral l-citrulline supplementation improves erectile function and penile structure in castrated rats” in the International Journal of Urology. They came to the conclusion that “Oral l-citrulline can improve the erectile response to electric stimulation of cavernous nerve and penile structure in castrated rats”. This is very interesting since the testosterone levels in the castrated rats had declined  significantly, which shows that nitric oxide supplements have a role to play that is as important as, if not more important than, testosterone.

The same Japanese researchers published another paper in October of 2013 titled “Oral L-citrulline supplementation improves erectile function in rats with acute arteriogenic erectile dysfunction” to assess whether or not supplementation with L-citrulline would be effective when the primary issue in the erectile dysfunction is poor blood perfusion.

They note: “Oral L-citrulline supplementation increases serum L-arginine levels more efficiently than L-arginine itself and increases nitric oxide (NO) production”. They concluded that supplementation was clinically effective in the treatment of this type of erectile dysfunction. Quoted from the article: “oral L-citrulline supplementation might be a useful novel therapy for acute arteriogenic ED.”

In the Journal of Nutrition Research, authors of an article titled “All-natural nitrite and nitrate containing dietary supplement promotes nitric oxide production and reduces triglycerides in humans” specifically tested a supplement combining beetroot, L-citrulline, and hawthorn extract. They found that “Patients taking the NO dietary supplement twice a day for 30 days led to a significant increase in systemic nitric oxide availability”.

It is quite obvious that adults over the age of forty would almost ubiquitously benefit from nitric oxide support in the form of adequate diet, aerobic exercise, and specific nitric oxide supplements. There are a great many reasons this statement is true and those reasons are all supported by the scientific literature. Nitric oxide is unquestionably one of the most important discoveries in the field of cardiovascular research in terms of the critical role it plays in the regulation of blood pressure and circulation. Since there seems to be no disgreement in the literature about the fact that cardiovascular health is closely tied to a significant percentage of erectile dysfunction cases, it would not seem to be inappropriate for individuals suffering with erectile dysfunction to take basic action and support nitric oxide production.

When something down means something’s up.

Erectile dysfunction is extremely common among middle-aged men. While ED carries with it many psycho-emotional concomitants that fill volumes, the condition has become well known to be the proverbial canary in the coal mine when it comes to other more serious health conditions.

You may have taken note of the introduction to commercials for drugs that portend to “cure” erectile dysfunction (ED) proclaiming it may be a problem with blood flow. For those circumstances not related to psychological issues such as anger and/or resentment towards the person you intend to have sex with, it is absolutely a matter of blood perfusion in almost every case. Any pathology that affects the arteries and results in inflammation, plaque formation, and rigidity in the vessels will manifest itself early on in the tiniest, most fragile arteries in the human body.

These are found in the peripheral tissues such as the hands, feet, intestines, brain, and penis. “It may be a matter of blood flow” is a completely true statement. And if this is the case, taking a pill that will boost nitric oxide production is a patch, not a cure. The reality is, if your smallest vessels are compromised by occlusion due to atheroma (plaque build up) then your least concern should be whether or not you “can get it up”.

There is good news, however. Studies over the past 17 years show that the propensity to develop a “stunned” artery system is a consequence of a reduced ability to produce nitric oxide at the level of the arterial artery wall. This is in many cases a genetic issue, but thankfully you can overcome this propensity by supplementing key factors involved in nitric oxide production.

No prescription required.
Studies show that the intake of nitric oxide precursors will massively increase the nitric oxide production capacity of the body. Dietary nitrates from beets, kale, spinach and other vegetables, along with polyphenols from pomegranates, cocoa, and hawthorne, and citrulline from foods such as watermelon rind are the absolute best sources of these precursors.

The intake of the aforementioned nutrients will enhance the body’s ability to produce nitric oxide and thereby increase the dilation of even the tiniest vessels, including those that supply the penis. Most people when supplying the body with these key ingredients will report positive changes in memory, concentration, libido, and yes, the ultimate ability to achieve and sustain an erection.

Because the body is actually undergoing physiological changes as a consequence of enhanced nitric oxide production, the results will most often be seen over a period of time such as 4-8 weeks. This may be seen as a downside when compared to the instant effect the prescription drugs can achieve, but this is the reason for the lengthy warning related to side effects. You may have noticed the commercials’ warning of an unsafe drop in blood pressure. This is due to the fact that nitric oxide is ramped up extremely quickly, causing the arteries to dilate dramatically, thereby lowering the pressure in the circulatory system quite suddenly and significantly. This sudden drop puts tremendous stress on the heart, which often results in an ominous outcome.

The commercials, if accurate, should stipulate that yes, erectile dysfunction is a matter of blood flow. Realize that this decreased blood flow is a consequence of the massive deficiency of essential nutrients that are no longer a part of the average American’s diet. And the reality is, the average person is gong to have to massively change their diet or take a pill to compensate.

Thoughtful Middle Aged Man

The only question is: are you, if you suffer from ED, going to take a drug to compensate for your average American dietary pattern and lifestyle? Or are you going to simply fulfill the requirement for the nutrients your body needs to sustain the level of health that is your birthright? Citrulline, pomegranate, Hawthorne, cocoa, etc. Take a pill or change your diet. If taking a pill, is it natural or is it a drug? Do you have a Viagra deficiency? Risk the side effects or reverse the process of atherosclerosis. The choice is, as always, yours.

Fortunately, there are great products on the market that will supply you with the necessary nutrients in pill form and not require you to do anything more than swallow. The best product this reviewer found is Nitroxyl. One glance at the ingredient list will astound the well informed. The formula contains every single extract and nutrient that can be even loosely connected with nitric oxide production and provides it at a price that is virtually impossible. The company that manufactures Nitroxyl purports to be in the business of furthering the endeavor of those seeking greater health and providing the opportunity to do so at minimal cost. This reviewer only hopes that they can continue to do so at the behest of those of us not holding degrees or being politically connected to those who do.

Look at the evidence behind each and every ingredient of Nitroxyl. Then pray, cross your fingers, touch wood, and add any other mechanism of wishfulness that this company and this product can survive so that we may do the same